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| Saysha Baker Photography | Pietermaritzburg | Photography | |
| SB Course | Small Business Consultant | Small Business Development | Business Course | ||
| SB Divers | Thailand | Entertainment | |
| SBG Cape Town | Gym | ||
| Sbls | Bellville | HR IR consulting, business restructuring, training | |
| SBS Battery | Kempton Park | Battery Manufacturing | |
| SC Resources | Johannesburg | Recruitment | |
| Scalliwags Costume Hire & Online Store | Alberton | Costume Hire / online ecommerce store | |
| Scan4U Scanning Services | Modderfontein | Document scanning services and scanning bureau | |
| Scana Pick | Personalized items | ||
| Scanlytix | Edmonton | Business to Business | |
| Scarce Graphix | Johannesburg | Multimedia Design, Website Development and Hosting | |
| Scarf World | Booysens | Online seller of fashion accessories | |
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| Scatterlings Conference & Events | PCO | ||
| Scents Booth | Fragrances and perfumes | ||
| Sceptre Insurance Brokers | Cape Town | Insurance Brokers | |
| Schaw Doors | Automated Doors | ||
| schilla interiors | Johannesburg | Wallpaper hangers | |
| Schlemmert Productions | Paarl | Professional Digital Video Productions | |
| ScholarOn | Houston | Education | |
| School Data Lists | Database Company | ||
| School of Light | Cape Town | Education | |
| School of Rock Claremont | Cape Town | Performance-based Music School | |
| Schwartz Door Solutions | Wilmington | Garage Doors | |
| Schweizer Garage Door Company | Phoenixville | Garage Door Supplier | |
| Sciencepeptide | Direct Marketing | ||
| SciTech Placements | Recruitment IT Engineering Science | ||
| Scoop Distribution | Cape Town | Networking and Telecommunications | |
| Scorprint Graphix | Johannesburg | Branding of clothing and corporate gifts | |
| Scott Crockett | Scott Crockett | ||
| Scott's Teambuilding Adventures | Westville | Teambuilding | |
| Scout Cloud | Stellenbosch | Digital & Influencer marketing agency | |
| Scratch Solutions | Edenvale | Branding of Corporate & Promotional Gifts | |
| Screan South Africa | Independant car inspection service | ||
| Screen Media | Johannesburg | LED Screen Specialists | |
| ScreenOcean | Johannesburg | Video Archive resellers | |
| ScreenQuip | Johannesburg | Big screens sound video lcd plasma stage | |
| Screw Compressor | Johannesberg | Air Compressor | |
| ScrumDumps | Healthforall | ||
| SCubeTutorials | Edcation | ||
| SDR Photo + Studio | Cape Town | Photography: fashion, lifestyle, catalogue, advert | |
| SDT Consulting | Durban | Construction Law Consultant | |
| SEA Hospitality Consultants (Pty) LTD | Port Elizabeth | Hospitality Consultant | |
| Sea Monster Entertainment | Zonnebloem | 2D Animation, Game Development | |
| Seagorcare | Blended yarn | ||
| Seagram Pearce Photography | Cape Town | Professional Photography | |
| SealQuip Industries | Pietermaritzburg | Gland Packing | |
| Seamless Events Solutions | Nairobi | Conferences and Corporate Events Management | |
| Seamless Gutter Pros | Johannesburg | Gutter cleaner | |
| Seamless Gutters Cape Town | Cape Town | Gutter | |
| Seamless Gutters East Rand | Johannesburg City | Gutter | |
| Seamless Gutters Johannesburg | Johannesburg City | Gutters | |
| Seamless Gutters Pretoria | Pretoria | Gutters | |
| Seamless Gutters Roodepoort | Roodepoort | Gutters | |
| Seamus Graphix | Durban | Graphic Design and Branding | |
| Search Fusion Online | Durban | SEO, Hosting, Website Development, Design | |
| Searchable | Searchable | ||
| SearchEngineInsight | Marketing | ||
| SearchMedia | Johannesburg | Online Marketing, SEO Services, App and Web Design | |
| SearchWise Solutions | George | Marketing, HR and Social Research | |
| Seattle State Farm Karrie Dubose | Seattle | financial | |
| Sebashe consultants and Field marketers | Kempton park | Direct marketing | |
| Secbands | Cape Town | Wristbands, Lanyards, Promo items | |
| Second Harvest | Cape Town | OOH master planning and business consulting | |
| Secondhand Scaffold For Sale | Pretoria | Supplier of Refurbished and New Scaffold | |
| Secret Sunrise Eastern Cape | Gqeberha | We run Secret Sunrise events | |
| Sectech | Rosslyn East | Industrial Dryers | |
| SecuPro Installations | Pretoria | Security Installation Company | |
| SecureASpot | Cape Town | Security Shutters, Doors, Gates, Blinds, Burglar P | |
| Security Business Capital | Midland | Invoice Factoring | |
| Security Smart | Durban | Automation Access Control Systems CCTV Gate Garage | |
| Security Warehouse Training Academy | Centurion | Security Installation Training | |
| Seed of Prosperity - Financial Wellness Experts | Johannesburg | Employee financial wellness for peak productivity | |
| Seek & Tell | Online Store | ||
| Segage Gardens and Landscaping | Bushbuckridge | gardening,lawn mowing, landscaping,grass cutting | |
| Segcom Group | Pinetown | Hardware and Software Support, Solar Systems | |
| Sekati Petroleum Energy and Technology | PRETORIA | Fuel wholesaler and Solar Energy, CCTV Installer, | |
| Sekkati Petroleum Energy and Technology | Pretoria | Petroleum, Satellite, Fibre, DSTV | |
| Sekunjalo Group | Cape Town | Broadcasting and Media | |
| Select Incentive Group Travel | Cape Town | Incentives & Events | |
| Selfie Cube | Gauteng | Photography , Photographer | |
| SelfieBox | Pretoria | Photo booth hire, GIF and Video booth rentals | |
| SellRent Ghana | Spintex | Brokerage, Marketing, Property Management, Agents, | |
| Selsaac Movers | Boksburg | Move your home and office furniture at reasonable | |
| Semantica Digital | Cape Town | Semantica Digital (Pty) Ltd | |
| Semex21 | vfdvdfvfdv | ||
| Semipoi Online | Semipoi Online Nonton Film Semi 2020 | ||
| Sengikwenzile Supplier Services | Durban | Road Freight Logistics | |
| SeniNhle Occupational Health Services | Pretoria | Asbestos, risk assessment, noise, ergonomics, HCS | |
| SeniNhle Occupational Health Sevices | Pretoria | Occupational health and safety, risk, hygiene | |
| Sensorpix Photography | Johannesburg | Sensorpix photography is people photography. | |
| Sentinel Commercial Services Group | Cape Town | Business Sales and Valuations | |
| Sentinels Leak Detection Services | Johannesburg | Leak Detection on property plumbing systems. | |
| Senzakahle Cleaning Projects | Kemptonpark | High quality professional cleaning company | |
| Seo Era Egypt | Cairo | SeoEra | |
| SEO Institute | Johannesburg | SEO & Brand Awarness | |
| SEO Results | South Africa | Search Engine Optimisation Analysis & Reports | |
| SEO Techpro Internet Marketing Carbondale IL | SEO Marketing |
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