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| Signature Windows and Doors | Stockton-On-Tees | Home Impovements, Window Installers | |
| SignForce | Johannesburg | Signage manufacture and installation in Africa | |
| SignForce South Africa | Johannesburg | Design manufacture & install signage CI | |
| Signium Africa | Johannesburg | C-suite and executive level talent sourcing | |
| Signs Of Arts | Cape town | wall murals signwriting art projects | |
| Signs360 | Johannesburg | Signage and Branding | |
| Signs4SA | Pretoria | Signage | |
| Signs4SA.co.za | Pretoria | Signage, Print, Branding and Retail Solutions | |
| Sigudlasitsuppliers | Johannesburg | Webdesign photo video motivation speaker branding | |
| Sikhosim Investment | BOKSBURG | Residential Rentals, water purification | |
| Sikwantu Npc | Cape Town | Marketing | |
| Silenced Generator Hire | Okahandja | Generator Hire | |
| Silent Rock Productions | Johannesburg | Television and corporate video production | |
| Silkmusic Wedding Djs | Cape Town | Wedding DJ | |
| Silva 5 Pets | Germiston | Sell products for pets | |
| Silver Bullet Productions | Cape Town | Film & Content Production | |
| Silver Chalk Design Studio | Pretoria | Visual Communication Specialists | |
| Silver Cloud Accounting | Cape Town | Accounting, Payroll & Business Advisory Services | |
| Silver Lining | Cape Town | Source & supply Corporate Gifts & Clothing | |
| Silver Linings Technologies | Pietermaritzburg | Website Design and SEO | |
| Silver Moon Media | Virgina | Videography | |
| Silver Ribbon Events | Johannesburg | Party /Function Hire Equipment | |
| Silver Screen Productions CC | South Africa | Video Production | |
| Silver Sieves Capital | Wall murals | ||
| Silver Solutions T/A About Turn Logistics | Cape Towwn | International and Domestic Courier, Air Freight | |
| Silverline Print | Vanderbijlpark | Label design & print | |
| Silverworx Staffing Solutions | Umhlanga | catering, events, mobile bartenders, waiters | |
| SILVERZONE IMAGES PHOTOGRAPHY | Ballito | Photography | |
| Silwer Lining Photography | Roodepoort | Newborn, maternity, cake smash photography | |
| SIMcontrol | Cape Town | Business SIM Management Platform | |
| Similia Investments | Johannesburg | Health | |
| Simmon Garage Door | Wilmington | Garage | |
| Simon Barnett Web Design and Development | Cape Town | Front End Web Development, Web Design | |
| Simon Dippenaar & Associates | Cape Town | Law firm | |
| Simon Ekin | Cape Town | life coaching, speaking, training | |
| Simons Designs | north riding | photography,printing | |
| Simpack | Marketing | ||
| Simpaul Design | Nairobi | Brand Identity | |
| SimpLee VA Services | Virtual Assistant Services | ||
| Simplex Time Recorders | Cape Town | Time and Attendance | |
| Simplify 360 | Bangalore | simplify 360 is the best review managment software | |
| Simplify Recruitment Services | Pretoria | Recruitment of staff | |
| Simplipf | UX & UI Design | ||
| Simplr Creative | Cape Town | Branding/UI & UX design | |
| Simply Chic Promos | Durban | Corporate Clothing | |
| Simply Cleaner | Cape Town | Cleaning of carpets/upholstery, etc | |
| Simply Digital Photomedia | Cape Town | Ernst Linde Photography | |
| Simply Exhibition Stands | Springs | Exhibition Stand Hire and Sales | |
| Simply Exhibitions Stands | Johannesburg | We are an Exhbition Stand Design and Build Company | |
| Simply Good Faith | Middelburg 1050 | Buying and Selling..Agricultural and On Demand goo | |
| Simply Visible SA | Johannesburg | Trailer and mobile billboard advertising | |
| simplySOLVED | Sandton | All-natural heath remedies, supplements and tonics | |
| Simpson Accounting (Pty) Ltd | Randburg | Accounting Services | |
| Sindicare Medical Suites | Durban | General Medical Services and Dental Services | |
| Singhs Attorneys | Johannesburg | Attorneys | |
| Singjohn.Com | singjohn | ||
| Singlebond | CENTURION | Web Design and Domain Hosting | |
| Sinister Studio | Post production | ||
| Sintasinta40 | SLOT | ||
| SIP Media | Johannesburg | SIP Media is a multi-faceted one stop media-hub | |
| Siphelwande Guesthouse | Maclear | Provide accommodation and conference facilities | |
| SIQNAL (Pty) Ltd | Bloemfontein | Web Development | |
| Siqobile Events Management and Catering | Johannesburg | Event planning and management, catering | |
| Sirdotcom Technology | Durban | System development and Web applications | |
| Sirticket | Johannesburg | Ticketing & Access Management | |
| Sistersystems | Newcastle | ICT Solutions | |
| SitePRO | Cape Town | Webdesign & Development | |
| SitesDeveloper | Randburg | Website design and development | |
| Sittings Restaurant and Bar | Mafikeng | Events, catering, accommodation, and creative desi | |
| Situsslotgalaxy138 | marketing | ||
| Sivatho Chuma Wealth Managers | Mthatha | Business Advisory | |
| Sivukile Liva Band | Ekurhuleni | Directors | |
| Sivukile Live Band | Ekurhuleni | Direct Marketing | |
| Siwengu | Soweto | Engage, survey and fan workshop | |
| Six Degrees Media | Sandton | Airline Advertising & Branding | |
| Six Fingaz Media | Johannesburg | South African Ad Agency based in Johannesburg. | |
| SixDigs Accounting | Johannesburg | Accounting/Tax/Bookkeeping/Consulting | |
| Sixfoot5 Digital | Search Engine Optimisation in Somerset West. | ||
| sixteenO2 | Randburg | Audio Imaging and Music Production | |
| Sixth Sense Manifesto | Ikoyi | Events, Digital marketing, Direct marketing | |
| Siyakhanya Leadership Africa | Johannesburg | Integrated brand and internal communications | |
| Siyakula Events | Centurion | Conceptualisting and management of events | |
| SiyaPromo | Springs | Socially impactful African marketing solutions | |
| Siyasebenza Manufacturing | Hammarsdale | Siyasebenza Manufacturing | |
| Siyaya Phambili Technology Solutions | Sandton | Direct Sales | |
| Siyembili Consulting & Business Services | Research & Business Consulting | ||
| Sizisa Industrial Supplies | Johannesburg | One stop supply co. Source & supply within 24 hrs. | |
| Sizwa Media | Photography/Videography Services | ||
| SJ Artists | Cape Town | Artist and project management agency. | |
| SJ Hydraulic/ Mechanical Repairs & Field Service | Rustenburg | Mechanical & Hydraulic Repairs | |
| SJ Webdesign Studio | Cape Town | Complete Website Design & Development | |
| SJC Creative | Randburg | media communications/writing/photography/pr | |
| SK Home | Cape Town | SK Home ushers luxury into your home. | |
| Skankane Transport | Nelspruit | Break Bulk | |
| Skhandzia Construction and Services | Johannesburg | General construction work,Civil and maintenance | |
| Skillogical | Roodepoort | People Development/HR Cloud Solutions | |
| Skills Academy | Pretoria | Home Study Courses |
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