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| Shakti Occasions | Johannesburg | Events and catering solutions | |
| Shans Accessories | Johannesburg | Accessories BMW, Merc, VW, Audi | |
| Shaperevengers | Johannesburg | Weight loss | |
| Sharp Tactical Security Sevices | Johannesburg | We provide Armrd & Un Arned Guards | |
| Shawn Driman Photography | Johannesburg | Commercial/Advertising Photography | |
| Sheba Marketing & Promotions | Pretoria | Event Management | |
| Sheer Glass | Sandton | Glass and aluminium supplier | |
| Sheetmetal Designs | Johannesburg | Design & manufacture of sheet metal products. | |
| Shereno Printers - Boksburg | Boksburg | Design, Layout, Print, Digital Large Format Print | |
| Sheshisa Online | Johannesburg | Grocery shopping and delivery services | |
| Shim Stock Metals | Johannesburg | Shim Stock Metal Manufacturer | |
| Shimba Marketing Distribution and Promotons | Randburg | Distribution and promotions | |
| Shiny Rock Polished | Johannesburg | Designer, Manufacturer, Seller of Jewellery | |
| SHIP Practitioners | Centurion | Consulting and Training Specialists | |
| Shipx | Randburg | Shipx logistics services | |
| Sho Craft Exhibitions | Roodepoort | Exhibition stand builders | |
| SHO MAN Media House | Boksburg | Event Filming | |
| Shoba-Comms | Johannesburg | Wall murals, building wraps and taxi branding | |
| Shocraft | Johannesburg | Exhibitions and Shopfitting | |
| Shomang Insurance Brokers | Edenvale | Insurance Broker for business, medical aid and pen | |
| Shop and Ship Online | Rivonia, Johannesburg | Full Apple product range, PC & Electronics online | |
| Shop Around | Pretoria | Eletronics Store | |
| Shopfitting Concepts | Pretoria | Manufacturing | |
| ShopNDeliver | Johannesburg | Grocery shopping and delivery | |
| Short Term Loans | Mr Cash Loans | Alberton | Loans | |
| Shortwave Productions | Johannesburg | Audio Post Production, Location Sound Recording | |
| Shot by Jeanne | Pretoria | conceptual photography and corporate photography | |
| Show TV | Johannesburg | Video, Photographic & Graphic Design Company | |
| ShowMe Pretoria | Pretoria | Website Development/Online Marketing | |
| Shubone Events | johannsburg | wedding and event planning,Hiring services,florist | |
| Shuttle King | Johannesburg | Johannesburg Airport Transfers, Shuttle Service | |
| Sibanzima Inspections | Midrand | Inspection of pressure vessels and compressors | |
| Sicon Group | Boksburg | Roof Contractor | |
| Side Kick Branding | Orange Grove | Marketing | |
| Sidekick Branding | Johannesburg | Signage Branding | |
| Sign Franchise | Sandton | Franchising | |
| Sign Image | Pretoria | Signage Company Gauteng | |
| Sign Image Digital | Pretoria | Signage, safety signs, poster frames, | |
| Sign Wonder | Alberton | Signage, Digital Printing | |
| Sign Wonder cc | Gauteng | Vehicle Branding, Promotional Printing | |
| Signa Artisans | Boksburg | Artisans Training | |
| Signa Group | Randburg | B-BBEE Consulting, Services, Solutions | |
| Signa Opportunity | Randburg | Youth Employment Services (YES) | |
| Signarama | Sandton | Signage | |
| SignForce | Johannesburg | Signage manufacture and installation in Africa | |
| SignForce South Africa | Johannesburg | Design manufacture & install signage CI | |
| Signium Africa | Johannesburg | C-suite and executive level talent sourcing | |
| Signs360 | Johannesburg | Signage and Branding | |
| Signs4SA | Pretoria | Signage | |
| Signs4SA.co.za | Pretoria | Signage, Print, Branding and Retail Solutions | |
| Sigudlasitsuppliers | Johannesburg | Webdesign photo video motivation speaker branding | |
| Sikhosim Investment | BOKSBURG | Residential Rentals, water purification | |
| Silenced Generator Hire | Okahandja | Generator Hire | |
| Silent Rock Productions | Johannesburg | Television and corporate video production | |
| Silva 5 Pets | Germiston | Sell products for pets | |
| Silver Chalk Design Studio | Pretoria | Visual Communication Specialists | |
| Silver Ribbon Events | Johannesburg | Party /Function Hire Equipment | |
| Silver Screen Productions CC | South Africa | Video Production | |
| Silver Sieves Capital | Wall murals | ||
| Silverline Print | Vanderbijlpark | Label design & print | |
| Silwer Lining Photography | Roodepoort | Newborn, maternity, cake smash photography | |
| Similia Investments | Johannesburg | Health | |
| Simons Designs | north riding | photography,printing | |
| Simplify Recruitment Services | Pretoria | Recruitment of staff | |
| Simply Exhibition Stands | Springs | Exhibition Stand Hire and Sales | |
| Simply Exhibitions Stands | Johannesburg | We are an Exhbition Stand Design and Build Company | |
| Simply Visible SA | Johannesburg | Trailer and mobile billboard advertising | |
| simplySOLVED | Sandton | All-natural heath remedies, supplements and tonics | |
| Simpson Accounting (Pty) Ltd | Randburg | Accounting Services | |
| Singhs Attorneys | Johannesburg | Attorneys | |
| Singlebond | CENTURION | Web Design and Domain Hosting | |
| Sinister Studio | Post production | ||
| SIP Media | Johannesburg | SIP Media is a multi-faceted one stop media-hub | |
| Siqobile Events Management and Catering | Johannesburg | Event planning and management, catering | |
| Sirticket | Johannesburg | Ticketing & Access Management | |
| SitesDeveloper | Randburg | Website design and development | |
| Sivukile Liva Band | Ekurhuleni | Directors | |
| Sivukile Live Band | Ekurhuleni | Direct Marketing | |
| Siwengu | Soweto | Engage, survey and fan workshop | |
| Six Degrees Media | Sandton | Airline Advertising & Branding | |
| Six Fingaz Media | Johannesburg | South African Ad Agency based in Johannesburg. | |
| SixDigs Accounting | Johannesburg | Accounting/Tax/Bookkeeping/Consulting | |
| sixteenO2 | Randburg | Audio Imaging and Music Production | |
| Siyakhanya Leadership Africa | Johannesburg | Integrated brand and internal communications | |
| Siyakula Events | Centurion | Conceptualisting and management of events | |
| SiyaPromo | Springs | Socially impactful African marketing solutions | |
| Siyaya Phambili Technology Solutions | Sandton | Direct Sales | |
| Siyembili Consulting & Business Services | Research & Business Consulting | ||
| Sizisa Industrial Supplies | Johannesburg | One stop supply co. Source & supply within 24 hrs. | |
| Sizwa Media | Photography/Videography Services | ||
| SJC Creative | Randburg | media communications/writing/photography/pr | |
| Skhandzia Construction and Services | Johannesburg | General construction work,Civil and maintenance | |
| Skillogical | Roodepoort | People Development/HR Cloud Solutions | |
| Skills Academy | Pretoria | Home Study Courses | |
| Skillset Consulting | Roodepoort | Consulting and training | |
| Skilltech Labour | Roodepoort | IT Placements and Labour Staffing | |
| Skin Renewal | Sandton | Anti-ageing and Aesthetic Clinic |
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