The robbery happened on 22 January 2018 at the couple's home in the village of Moulsford in southeast England, according to the Daily Mail, which said the cryptocurrency crime was the first of its kind.
Four robbers wearing balaclavas broke into the house of Danny Aston, 30, and his wife Amy Jay, 31.
A Thames Valley Police spokesman quoted by the Daily Telegraph said only that police were investigating an "aggravated burglary" in Moulsford last week and that the occupants of the house had been "threatened".
According to company registry records, Aston and Jay are directors of Aston Digital Currencies, which specialises in managing virtual currency portfolios.
The company was created in June 2017 at a time when Bitcoin was trading at around 2,500 euros.
It has since risen sharply to a peak of 16,323 euros on December 17 before falling back below 10,000 euros.
No arrests have been made but the reports said that Aston may have been targeted because of his high profile in the cryptocurrency community.
Using a pseudonym, Aston has carried out more than 100,000 transactions with 16,375 partners.
Some of them referred to him online using his real name, which may have led robbers directly to him.
Bitcoin is a virtual currency created from computer code that allows anonymous transactions. Unlike a real-world unit such as the US dollar or euro, it has no central bank and is not backed by any government.
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